Abstract

The triggering receptor expressed on myeloid cells 1 (TREM-1) is an innate immunity receptor associated with the amplification of inflammation in sterile and non-sterile inflammatory disorders. Since its first description, the two isoforms of the receptor, membrane and soluble (mTREM-1 and sTREM-1, respectively) have been largely explored in the immunopathogenesis of several bacterial diseases and sepsis. The role of the receptor in these scenarios seems to be at least partly dependent on the source/type of bacteria, host and context. As uncontrolled inflammation is a result of several bacterial infections, the inhibition of the receptor has been considered as a promising approach to treat such conditions. Further, sTREM-1 has been explored as a biomarker for diagnosis and/or prognosis of several bacterial diseases. Therefore, this review aims to provide an updated insight into how the receptor influences and is influenced by bacterial infections, highlighting the advances regarding the use/manipulation of TREM-1 isoforms in biomedical research and clinical practice.

摘要

髓样细胞1（TREM-1）上表达的触发受体是一种先天性免疫受体，与无菌和非无菌炎症疾病中的炎症放大相关。自从首次描述以来，已经在几种细菌性疾病和败血症的免疫发病机理中广泛探索了受体的两种同工型：膜和可溶性（分别为mTREM-1和sTREM-1）。在这些情况下，受体的作用似乎至少部分取决于细菌的来源/类型，宿主和环境。由于不受控制的炎症是几种细菌感染的结果，因此认为抑制受体是治疗此类疾病的一种有前途的方法。此外，已经探索了sTREM-1作为用于几种细菌性疾病的诊断和/或预后的生物标记。所以，