Lipid droplets and autophagy—links and regulations from yeast to humans,Journal of Cellular Biochemistry

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Lipid droplets and autophagy—links and regulations from yeast to humans
Journal of Cellular Biochemistry ( IF 3.0 ) Pub Date : 2021-01-31 , DOI: 10.1002/jcb.29889
Jana Schepers ₁ , Christian Behl ₁

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Recent advances in the yeast Saccharomyces cerevisiae and higher eukaryotes have been increasingly connecting lipid droplet (LD) dynamics to the regulation of autophagy. In this review we will discuss implications that connect LD de novo synthesis and LD mobilization to autophagy and how autophagy is regulated by these mechanisms. Elucidating these connections might pose a chance to further understand autophagy induction and membrane biogenesis for the growing autophagosome under different conditions. Increasing our understanding of these mechanisms might provide a chance to understand several conditions that might be related to LD dysregulation and, possibly, as a consequence of this, dysregulation of autophagy.

中文翻译：

脂滴和自噬——从酵母到人类的联系和调控

酵母酿酒酵母和高等真核生物的最新进展越来越多地将脂滴 (LD) 动力学与自噬调节联系起来。在这篇综述中，我们将讨论将 LD从头合成和 LD 动员与自噬联系起来的含义，以及这些机制如何调节自噬。阐明这些联系可能为进一步了解不同条件下生长的自噬体的自噬诱导和膜生物发生提供机会。增加我们对这些机制的理解可能会提供一个机会来了解可能与 LD 失调有关的几种情况，并且可能因此导致自噬失调。

更新日期：2021-01-31

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