Ulcerative colitis is an autoimmune inflammatory disorder with a negative impact on the life quality of patients. Cinnamaldehyde and hesperetin were chosen due to their antioxidants and anti‐inflammatory effects. This study explored the protective effects of cinnamaldehyde (40 and 90 mg/kg, po) and hesperetin (50 and 100 mg/kg, po) on 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced ulcerative colitis in rats. Cinnamaldehyde and hesperetin significantly improved macroscopic and histopathological examinations with a significant reduction in myeloperoxidase and intracellular adhesion molecule‐1 expression. They significantly reduced colon oxidative stress by a significant elevation in both reduced glutathione content and superoxide dismutase activity with a significant reduction of NO content. Furthermore, cinnamaldehyde and hesperetin alleviated the inflammatory injury by a significant reduction in interleukin‐6 along with suppression of nuclear factor‐κB, receptor for advanced glycation end products, and tumor necrosis factor‐α expression. Moreover, cinnamaldehyde and hesperetin significantly decreased p‐JAK2 and p‐STAT3 while significantly increased suppressors of cytokine signaling 3 (SOCS3) protein expression. In conclusion, cinnamaldehyde and hesperetin counteracted TNBS‐induced ulcerative colitis through antioxidant, anti‐inflammatory properties as well as modulation of the JAk2/STAT3/SOCS3 pathway.

中文翻译：

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肉桂醛和橙皮素通过调节JAk2 / STAT3 / SOCS3途径减轻TNBS诱导的大鼠溃疡性结肠炎

溃疡性结肠炎是一种自身免疫性炎性疾病，对患者的生活质量有负面影响。选择肉桂醛和橙皮素是因为它们具有抗氧化剂和抗炎作用。这项研究探讨了肉桂醛（40和90 mg / kg，口服）和橙皮素（50和100 mg / kg，口服）对2,4,6-三硝基苯磺酸（TNBS）诱导的大鼠溃疡性结肠炎的保护作用。肉桂醛和橙皮素显着改善了宏观和组织病理学检查，髓过氧化物酶和细胞内粘附分子-1的表达显着降低。它们通过降低谷胱甘肽含量和超氧化物歧化酶活性显着提高，从而显着降低结肠氧化应激，同时显着降低NO含量。此外，肉桂醛和橙皮素可显着减少白细胞介素-6的含量，并抑制核因子-κB，晚期糖基化终产物的受体和肿瘤坏死因子-α的表达，从而减轻了炎症性损伤。此外，肉桂醛和橙皮素显着降低了p-JAK2和p-STAT3，同时显着增加了细胞因子信号传导3（SOCS3）蛋白表达的抑制因子。总之，肉桂醛和橙皮素可通过抗氧化剂，抗炎特性以及对JAk2 / STAT3 / SOCS3途径的调节来抵消TNBS诱导的溃疡性结肠炎。肉桂醛和橙皮素显着降低了p-JAK2和p-STAT3，同时显着增加了细胞因子信号传导3（SOCS3）蛋白表达的抑制因子。总之，肉桂醛和橙皮素可通过抗氧化剂，抗炎特性以及对JAk2 / STAT3 / SOCS3途径的调节来抵消TNBS诱导的溃疡性结肠炎。肉桂醛和橙皮素显着降低了p-JAK2和p-STAT3，同时显着增加了细胞因子信号传导3（SOCS3）蛋白表达的抑制因子。总之，肉桂醛和橙皮素可通过抗氧化剂，抗炎特性以及对JAk2 / STAT3 / SOCS3途径的调节来抵消TNBS诱导的溃疡性结肠炎。