Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate,Cell Proliferation

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Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-01 , DOI: 10.1111/cpr.12998
Kai Sun ₁ , Jiachao Guo ₁ , Xudong Yao ₁ , Zhou Guo ₁ , Fengjing Guo ₁

Affiliation

Growth differentiation factor 5 (GDF‐5) is essential for cartilage development and homeostasis. The expression and function of GDF‐5 are highly associated with the pathogenesis of osteoarthritis (OA). OA, characterized by progressive degeneration of joint, particularly in cartilage, causes severe social burden. However, there is no effective approach to reverse the progression of this disease. Over the past decades, extensive studies have demonstrated the protective effects of GDF‐5 against cartilage degeneration and defects. Here, we summarize the current literature describing the role of GDF‐5 in development of cartilage and joints, and the association between the GDF‐5 gene polymorphisms and OA susceptibility. We also shed light on the protective effects of GDF‐5 against OA in terms of direct GDF‐5 supplementation and modulation of the GDF‐5‐related signalling. Finally, we discuss the current limitations in the application of GDF‐5 for the clinical treatment of OA. This review provides a comprehensive insight into the role of GDF‐5 in cartilage and emphasizes GDF‐5 as a potential therapeutic candidate in OA.

中文翻译：

软骨和骨关节炎中的生长分化因子 5：一种可能的治疗候选者

生长分化因子 5 (GDF-5) 对于软骨发育和体内平衡至关重要。 GDF-5的表达和功能与骨关节炎（OA）的发病机制高度相关。 OA以关节（尤其是软骨）进行性退化为特征，造成严重的社会负担。然而，没有有效的方法来逆转这种疾病的进展。在过去的几十年里，广泛的研究已经证明了 GDF-5 对软骨退化和缺损的保护作用。在此，我们总结了当前描述 GDF-5 在软骨和关节发育中的作用以及GDF-5基因多态性与 OA 易感性之间关系的文献。我们还通过直接补充 GDF-5 和调节 GDF-5 相关信号传导，阐明了 GDF-5 对 OA 的保护作用。最后，我们讨论了目前 GDF-5 在 OA 临床治疗中应用的局限性。这篇综述全面介绍了 GDF-5 在软骨中的作用，并强调 GDF-5 作为 OA 的潜在治疗候选药物。

更新日期：2021-03-09

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