Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence,Cell Proliferation

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Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-01 , DOI: 10.1111/cpr.12991
Xiaoying Luo _{1,

2} , Yangqiu Bai ₁ , Shuli He ₁ , Suofeng Sun _{1,

2} , Xiaoke Jiang ₁ , Zhiyu Yang _{1,

2} , Di Lu _{1,

2} , Peiru Wei ₁ , Yuan Liang ₁ , Cong Peng ₁ , Yaru Wang ₁ , Ruli Sheng ₁ , Shuangyin Han ₁ , Xiuling Li ₁ , Bingyong Zhang ₁

Affiliation

Premature senescence is related to progerin and involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis. However, the mechanisms of premature senescence in defenestration of hepatic sinusoidal endothelial cells (HSECs) and how SIRT1 affects HSECs fenestrae remain elusive.

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