CTGF facilitates cell‐cell communication in chondrocytes via PI3K/Akt signalling pathway,Cell Proliferation

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CTGF facilitates cell‐cell communication in chondrocytes via PI3K/Akt signalling pathway
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-01 , DOI: 10.1111/cpr.13001
Zuping Wu ₁ , Chenchen Zhou ₁ , Quan Yuan ₁ , Demao Zhang ₁ , Jing Xie ₁ , Shujuan Zou _{1,

2}

Affiliation

Gap junction intercellular communication (GJIC) is essential for articular cartilage to respond appropriately to physical or biological stimuli and maintain homeostasis. Connective tissue growth factor (CTGF), identified as an endochondral ossification genetic factor, plays a vital role in cell proliferation, migration and adhesion. However, how CTGF regulates GJIC in chondrocytes is still unknown. This study aims to explore the effects of CTGF on GJIC in chondrocytes and its potential biomechanism.

中文翻译：

CTGF通过PI3K / Akt信号通路促进软骨细胞之间的细胞间通讯

间隙连接细胞间通讯（GJIC）对于关节软骨对物理或生物刺激做出适当反应并维持体内稳态至关重要。结缔组织生长因子（CTGF）被鉴定为软骨内骨化的遗传因子，在细胞增殖，迁移和粘附中起着至关重要的作用。但是，CTGF如何调节软骨细胞中的GJIC仍是未知的。本研究旨在探讨CTGF对软骨细胞GJIC的影响及其潜在的生物机制。

更新日期：2021-03-09

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