It is important to prepare ‘hypoimmunogenic’ or ‘universal’ human pluripotent stem cells (hPSCs) with gene‐editing technology by knocking out or in immune‐related genes, because only a few hypoimmunogenic or universal hPSC lines would be sufficient to store for their off‐the‐shelf use. However, these hypoimmunogenic or universal hPSCs prepared previously were all genetically edited, which makes laborious processes to check and evaluate no abnormal gene editing of hPSCs.

中文翻译：

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混合供体来源的胎儿干细胞衍生的人诱导多能干细胞及其分化细胞的通用细胞的瞬态特征

通过基因敲除或免疫相关基因的制备，使用基因编辑技术制备“低免疫原性”或“通用”人多能干细胞（hPSC）是很重要的，因为只有少数低免疫原性或通用的hPSC系足以存储它们现成的使用。但是，先前制备的这些低免疫原性或通用的hPSC都经过了基因编辑，这使得检查和评估hPSC的异常基因编辑过程很费力。