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Reducing TGF‐β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34+ cells by inhibiting AhR signalling
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-01-31 , DOI: 10.1111/cpr.12999 Xuejun Zhu 1 , Qihao Sun 1 , Wen‐song Tan 1 , Haibo Cai 1
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-01-31 , DOI: 10.1111/cpr.12999 Xuejun Zhu 1 , Qihao Sun 1 , Wen‐song Tan 1 , Haibo Cai 1
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As an inhibitor of the AhR signalling pathway, StemRegenin 1 (SR1) not only promotes the expansion of CD34+ cells but also increases CD34− cell numbers. These CD34− cells influenced the ex vivo expansion of CD34+ cells. In this work, the effects of periodically removing CD34− cells combined with SR1 addition on the ex vivo expansion and biological functions of HSCs were investigated.
中文翻译：
降低TGF-β1与StemRegenin 1的合作通过抑制AhR信号传导促进脐血CD34 +细胞的离体扩增
作为的AhR信号传导途径的抑制剂，StemRegenin 1（SR1）不仅促进CD34的膨胀+细胞，但也增加了CD34 -细胞的数量。这些CD34 -细胞的影响CD34的体外扩增+细胞。在这项工作中，周期性地取出CD34的影响-细胞与SR1除了在离体扩增造血干细胞和生物功能结合进行了研究。
更新日期：2021-03-09
中文翻译：
降低TGF-β1与StemRegenin 1的合作通过抑制AhR信号传导促进脐血CD34 +细胞的离体扩增
作为的AhR信号传导途径的抑制剂，StemRegenin 1（SR1）不仅促进CD34的膨胀+细胞，但也增加了CD34 -细胞的数量。这些CD34 -细胞的影响CD34的体外扩增+细胞。在这项工作中，周期性地取出CD34的影响-细胞与SR1除了在离体扩增造血干细胞和生物功能结合进行了研究。
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