MicroRNA regulation of cholesterol metabolism,Annals of the New York Academy of Sciences

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MicroRNA regulation of cholesterol metabolism
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2021-01-31 , DOI: 10.1111/nyas.14566
Kathryn M Citrin _{1,

2} , Carlos Fernández-Hernando ₁ , Yajaira Suárez ₁

Affiliation

MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level. Since many microRNAs have multiple mRNA targets, they are uniquely positioned to regulate the expression of several molecules and pathways simultaneously. For example, the multiple stages of cholesterol metabolism are heavily influenced by microRNA activity. Understanding the scope of microRNAs that control this pathway is highly relevant to diseases of perturbed cholesterol metabolism, most notably cardiovascular disease (CVD). Atherosclerosis is a common cause of CVD that involves inflammation and the accumulation of cholesterol-laden cells in the arterial wall. However, several different cell types participate in atherosclerosis, and perturbations in cholesterol homeostasis may have unique effects on the specialized functions of these various cell types. Therefore, our review discusses the current knowledge of microRNA-mediated control of cholesterol homeostasis, followed by speculation as to how these microRNA–mRNA target interactions might have distinctive effects on different cell types that participate in atherosclerosis.

中文翻译：

MicroRNA 调节胆固醇代谢

MicroRNA 是在转录后水平调节基因表达的小型非编码 RNA。由于许多 microRNA 具有多个 mRNA 靶标，因此它们具有独特的定位，可以同时调节多个分子和途径的表达。例如，胆固醇代谢的多个阶段受到 microRNA 活性的严重影响。了解控制该途径的 microRNA 的范围与胆固醇代谢紊乱的疾病高度相关，尤其是心血管疾病 (CVD)。动脉粥样硬化是心血管疾病的常见原因，它涉及炎症和动脉壁中富含胆固醇的细胞的积累。然而，几种不同的细胞类型参与动脉粥样硬化，胆固醇稳态的扰动可能对这些不同细胞类型的特殊功能产生独特的影响。因此，我们的综述讨论了当前关于 microRNA 介导的胆固醇稳态控制的知识，然后推测这些 microRNA-mRNA 靶标相互作用如何对参与动脉粥样硬化的不同细胞类型产生独特的影响。

更新日期：2021-01-31

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