Among 15 plant methanol extracts, Piper kadsura stem extract (PkSE) showed the strongest larvicidal activity against Aedes albotictus. Larvicidal activities of P. kadsura stem extract were 100 % and 80 % at 0.01 and 0.005 mg/mL concentrations, respectively. Two isobutyl amides, pellitorine and chingchengenamide A, and one neolignan, piperenone, were isolated as active compounds from PkSE. Larvicidal activities of chingchengenamide A, piperenone, and pellitorine were 100 %, 100 %, and 87.5 % at 0.005 mg/mL concentration, respectively, and 100 %, 67.5 %, and 15.0 % at 0.0025 mg/mL. Cellulose nanocrystal (CNC)-stabilized Pickering emulsion of PkSE was developed, and its larvicidal activity was slightly higher than that of pure PkSE. Acute oral and dermal toxicity of PkSE toward rat, Rattus norvegicus, was >2000 mg/kg body weight. Acute contact toxicity of PkSE to honeybee was >100 μg/bee. The no observed effect concentration (NOEC) of PkSE to Oryzias latipes was 0.031 mg/mL.

在15种植物甲醇提取物中，Piper kadsura茎提取物（PkSE）对白纹伊蚊表现出最强的杀幼虫活性。蚊的活动P.冷饭茎提取物在0.01和0.005 mg / mL的浓度下分别为100％和80％。从PkSE中分离出了两种异丁酰胺酰胺，去甲肾上腺素和chingchengenamide A，以及一种新木脂素，哌啶酮作为活性化合物。在0.005 mg / mL的浓度下，chingchengenamide A，哌雷酮和pellitorine的杀幼虫活性分别为100％，100％和87.5％，在0.0025 mg / mL的情况下分别为100％，67.5％和15.0％。开发了纤维素纳米晶体（CNC）稳定的PkSE Pickering乳液，其杀幼虫活性略高于纯PkSE。PkSE对大鼠Rattus norvegicus的急性经口和经皮毒性大于2000 mg / kg体重。PkSE对蜜蜂的急性接触毒性为> 100μg/只蜜蜂。最大无作用浓度（NOEC）PkSE到青鳉 为0.031 mg / mL。