A total diet study (TDS) was conducted in France to assess the health risks related to the chemicals in food of non-breastfed children under three years of age (Infant TDS). For the first time, substances coming from food contact materials, such as bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE) and its derivatives, some phthalates, and some ink photoinitiators, were targeted because of growing interest in these substances. Food samples were collected to be representative of the whole diet of non-breastfed children aged 1–36 months, and prepared as consumed prior to analysis. Dietary exposure was assessed for 705 representative children under three years of age. Generally, the substances from food contact materials were detected in few samples: 38% for BPA, 0% for BADGE and its derivatives, 0–35% for phthalates, 1.9% for benzophenone, and 0% for the other ink photoinitiators. Regarding exposure levels, the situation was deemed tolerable for BADGE and its hydrolysis products, di-isodecyl phthalate, dibutyl phthalate, butyl benzyl phthalate, bis(2-ethylhexyl) phthalate, and di-isononyl phthalate, benzophenone, and 4-methylbenzophenone. Only for BPA, the exposure levels of some children exceeded the lowest toxicological value established by the French Agency for Food, Environmental and Occupational Health & Safety at 0.083 µg.kg bw⁻¹.d⁻¹. The temporary tolerable daily intake of the European Food Safety Authority (EFSA), set at 4 µg.kg bw⁻¹.d⁻¹, was never exceeded. However, actual exposure to BPA was probably overestimated, as well as the associated risk, because the foods were sampled prior to the recent regulations banning BPA in food packaging. This study is the first worldwide to provide an estimate of infant food contamination levels and exposures of children under 3 years of age, based on a TDS approach. It therefore provides key data on the exposure of this particularly sensitive population to substances released from food contact materials, and presents useful data for studies evaluating exposure to mixtures or aggregated exposure.

在法国进行了一项全面饮食研究 (TDS)，以评估与三岁以下非母乳喂养儿童食物中的化学物质相关的健康风险 (婴儿 TDS)。由于对这些物质的兴趣日益浓厚，来自食品接触材料的物质（例如双酚 A (BPA)、双酚 A 二缩水甘油醚 (BADGE) 及其衍生物、一些邻苯二甲酸酯和一些油墨光引发剂）首次成为目标。收集食物样本以代表 1-36 个月的非母乳喂养儿童的整个饮食，并在分析前准备好食用。对 705 名 3 岁以下具有代表性的儿童进行了膳食暴露评估。一般来说，在少数样品中检测到来自食品接触材料的物质：BPA 为 38%，BADGE 及其衍生物为 0%，邻苯二甲酸盐为 0-35%，二苯甲酮为 1.9%，其他油墨光引发剂为 0%。关于暴露水平，BADGE 及其水解产物邻苯二甲酸二异癸酯、邻苯二甲酸二丁酯、邻苯二甲酸丁苄酯、邻苯二甲酸二（2-乙基己基）酯、邻苯二甲酸二异壬酯、二苯甲酮和 4-甲基二苯甲酮的暴露水平被认为是可以忍受的。仅对于双酚 A，一些儿童的接触水平超过了法国食品、环境和职业健康与安全机构确定的最低毒理学值 0.083 µg.kg bw^-1 .d ^-1。欧洲食品安全局 (EFSA) 的临时可耐受每日摄入量设定为 4 µg.kg bw ^-1 .d ^-1，从未超过。然而，可能高估了 BPA 的实际暴露量以及相关风险，因为这些食品是在最近禁止食品包装中 BPA 的法规之前对食品进行取样的。这项研究是世界上第一个基于 TDS 方法对 3 岁以下儿童的婴儿食品污染水平和暴露量进行估计的研究。因此，它提供了有关这一特别敏感人群接触从食品接触材料释放的物质的关键数据，并为评估接触混合物或总接触的研究提供了有用的数据。