Surfactants are commonly found in today's world as an essential component of cleaning detergents, cosmetics and drug delivery systems. They can penetrate into lipid membranes, thus changing their properties. The aim of this paper is to compare the effect of addition of small amounts of cationic (DTAB) and anionic surfactants (SDS) with the same alkyl chain length on the zeta potential of DPPC liposomes with their influence on the corresponding DPPC monolayers. It was found that the addition of ionic surfactants with an initial concentration in the solution equal to 2.3, 4.5 and 9.1 μM to the liposome suspension changes their electrokinetic potential significantly. These changes increase with the increasing surfactant concentration and are greater for the anionic surfactant. This indicates the incorporation of surfactants into the structure of liposomes. Based on the analysis of π-area isotherms of DPPC monolayers it was proved that the ionic surfactant molecules are irreversibly integrated into the DPPC monolayer.

表面活性剂是当今世界常见的清洁剂、化妆品和药物输送系统的重要组成部分。它们可以渗透到脂质膜中，从而改变它们的特性。本文的目的是比较添加少量具有相同烷基链长度的阳离子 (DTAB) 和阴离子表面活性剂 (SDS) 对 DPPC 脂质体 zeta 电位的影响及其对相应 DPPC 单层的影响。发现将溶液中初始浓度等于 2.3、4.5 和 9.1 μM 的离子表面活性剂添加到脂质体悬浮液中会显着改变其电动势。这些变化随着表面活性剂浓度的增加而增加，并且对于阴离子表面活性剂更大。这表明表面活性剂掺入到脂质体的结构中。基于对 DPPC 单层的 π 面积等温线的分析，证明离子表面活性剂分子不可逆地整合到 DPPC 单层中。