Significance: Oxygenation is one of the skin tissue physiological properties to follow for patient care management. Furthermore, long-term monitoring of such parameters is needed at the patient bed as well as outside the hospital. Diffuse reflectance spectroscopy has been widely used for this purpose. Aim: The aim of the study is to propose a low-cost system for the long-term measurement of skin physiological parameters in contact. Approach: We have developed a low-cost, wearable, CMOS-based device. We propose an original method for processing diffuse reflectance data to calculate the tissue oxygen saturation (StO2). Results: We tested the device for the assessment of tissue oxygenation during a first-in-human clinical trial that took place at the Grenoble University Hospital France. Conclusions: The results of this clinical trial show a good accordance between our sensor and commercial devices used a reference.

中文翻译：

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用于皮肤状况诊断的接触式高分辨率空间漫反射成像系统：首次人体临床试验

意义：氧合是患者护理管理所遵循的皮肤组织生理特性之一。此外，需要在病床和医院外对这些参数进行长期监测。漫反射光谱已广泛用于此目的。目的：该研究的目的是提出一种用于长期测量接触皮肤生理参数的低成本系统。方法：我们开发了一种低成本、可穿戴、基于 CMOS 的设备。我们提出了一种处理漫反射数据以计算组织氧饱和度 (StO2) 的原始方法。结果：我们在法国格勒诺布尔大学医院进行的首次人体临床试验中测试了用于评​​估组织氧合的设备。结论：