Early afterdepolarizations (EADs) in cardiac myocytes have been reported to be associated with a series of cardiac arrhythmias. The generation of EADs has a high correlation with the excitation period, leading to repolarization dispersion over the cardiac tissue. However, the mechanism of EAD rate dependence has not been thoroughly revealed. In this study, the simulation approach was used to investigate the mechanism underlying EAD rate dependence. The results indicated that the gating variable of the delayed rectifier potassium current ([Formula: see text]-gate) and the intracellular sodium ion concentration ([Na[Formula: see text]][Formula: see text] were key factors contributing to EAD rate dependence. Also, different mathematical models showed different types of EAD rate dependence, which needs to be considered in the future simulation research related to EADs.

中文翻译：

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去极化后早期率依赖性的关键因素：一项模拟研究

据报道，心肌细胞中的早期后除极 (EAD) 与一系列心律失常有关。EADs 的产生与激发周期高度相关，导致心脏组织的复极化分散。然而，EAD率依赖的机制尚未彻底揭示。在本研究中，模拟方法用于研究 EAD 速率依赖性的机制。结果表明，延迟整流钾电流的门控变量（[公式：见文]-门）和细胞内钠离子浓度（[Na[公式：见文]][公式：见文]是影响EAD 速率依赖。此外，不同的数学模型显示了不同类型的 EAD 速率依赖，