Actinobacteria is a large and diverse phylum of bacteria that contains medically and ecologically relevant organisms. Many members are valuable sources of bioactive natural products and chemical precursors that are exploited in the clinic and made using the enzyme pathways encoded in their complex genomes. Whilst the number of sequenced genomes has increased rapidly in the last 20 years, the large size, complexity and high G+C content of many actinobacterial genomes means that the sequences remain incomplete and consist of large numbers of contigs with poor annotation, which hinders large-scale comparative genomic and evolutionary studies. To enable greater understanding and exploitation of actinobacterial genomes, specialized genomic databases must be linked to high-quality genome sequences. Here, we provide a curated database of 612 high-quality actinobacterial genomes from 80 genera, chosen to represent a broad phylogenetic group with equivalent genome re-annotation. Utilizing this database will provide researchers with a framework for evolutionary and metabolic studies, to enable a foundation for genome and metabolic engineering, to facilitate discovery of novel bioactive therapeutics and studies on gene family evolution. This article contains data hosted by Microreact.

中文翻译：

---

ActDES – 用于进化研究的精选放线菌数据库


放线菌是一个庞大而多样的细菌门，包含医学和生态相关的生物体。许多成员都是生物活性天然产物和化学前体的宝贵来源，这些天然产物和化学前体在临床中得到利用，并利用其复杂基因组中编码的酶途径制成。虽然已测序的基因组数量在过去 20 年中迅速增加，但许多放线菌基因组的大尺寸、复杂性和高 G+C 含量意味着序列仍然不完整，并且由大量注释较差的重叠群组成，这阻碍了大规模测序。 -规模比较基因组和进化研究。为了更好地理解和利用放线菌基因组，专门的基因组数据库必须与高质量的基因组序列相关联。在这里，我们提供了一个包含来自 80 个属的 612 个高质量放线菌基因组的数据库，这些基因组被选择来代表具有等效基因组重新注释的广泛系统发育群体。利用该数据库将为研究人员提供进化和代谢研究的框架，为基因组和代谢工程奠定基础，促进新型生物活性疗法的发现和基因家族进化的研究。本文包含 Microreact 托管的数据。