Rheumatic diseases are complex autoimmune diseases which include among others rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA). These diseases are characterized by prolonged and increased secretion of inflammatory factors, eventually leading to inflammation. This is often accompanied by persistent pain and stiffness in the joint and finally bone destruction and osteoporosis. These diseases can occur at any age, regardless of gender or origin. Autoimmune arthritis is admittedly associated with long-term treatment, and discontinuation of medication is associated with unavoidable relapse. Therefore, it is important to detect the disease at an early stage and apply appropriate preventative measures. During inflammation, pro-inflammatory factors such as interleukins (IL)-6, -17, -21, -22, and -23 are secreted, while anti-inflammatory factors including IL-10 are downregulated. Research conducted over the past several years has focused on inhibiting inflammatory pathways and activating anti-inflammatory factors to improve the quality of life of people with rheumatic diseases. The aim of this paper is to review current knowledge on stimulatory and inhibitory pathways involving the signal transducer and activator of transcription 3 (STAT3). STAT3 has been shown to be one of the crucial factors involved in inflammation and is directly linked with other pro-inflammatory factors and thus is a target of current research on rheumatoid diseases.

风湿性疾病是复杂的自身免疫性疾病，其中包括类风湿性关节炎（RA）、幼年特发性关节炎（JIA）和银屑病关节炎（PsA）。这些疾病的特点是炎症因子分泌时间延长且增加，最终导致炎症。这通常伴随着关节的持续疼痛和僵硬，最终导致骨质破坏和骨质疏松。这些疾病可以发生在任何年龄，无论性别或出身。不可否认，自身免疫性关节炎与长期治疗有关，停药与不可避免的复发有关。因此，及早发现疾病并采取适当的预防措施非常重要。在炎症过程中，白介素 (IL)-6、-17、-21、-22 和 -23 等促炎因子被分泌，而包括 IL-10 在内的抗炎因子则下调。过去几年进行的研究主要集中在抑制炎症途径和激活抗炎因子，以改善风湿性疾病患者的生活质量。本文的目的是回顾当前关于涉及信号转导子和转录激活子 3 (STAT3) 的刺激和抑制通路的知识。 STAT3已被证明是参与炎症的关键因子之一，并与其他促炎因子直接相关，因此是当前类风湿疾病研究的目标。