Objective. Most of the previous studies of drone transport of blood samples examined normal blood samples transported under tranquil air conditions. We studied the effects of 1- and 2-hour drone flights using random vibration and turbulence simulation (10-30 g-force) on blood samples from 16 healthy volunteers and 74 patients with varying diseased. Methods: Thirty-two of the most common analytes were tested. For biochemical analytes, we used plasma collected in lithium heparin tubes with and without separator gel. Gel samples were analyzed for the effect of separation by centrifugation before or after turbulence. Turbulence was simulated in an LDS V8900 high-force shaker using random vibration (range, 5–200 Hz), with samples randomly allocated to 1- or 2-hour flights with 25 or 50 episodes of turbulence from 10 to 30 G. Results: For all hematologic and most biochemical analytes, test results before and after turbulence exposure were similar (bias < 12%, intercepts < 10%). However, aspartate aminotransferase, folate, lactate dehydrogenase and lipid index increased significantly in samples separated by gel and centrifugation prior to vibration and turbulence test. These changes increased form 10 G to 30 G, but were not observed when the samples were separated after vibration and turbulence. Conclusions: Whole blood showed little vulnerability to turbulence, whereas plasma samples separated from blood cells by gel may be significantly influenced by turbulence when separated by spinning before the exposure. Centrifugation of plasma samples collected in tubes with separator gel should be avoided before drone flights that could be subject to turbulence.

中文翻译：

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病理血液样本可以承受模拟无人机飞行中的振动和高湍流，但血浆样本应在飞行后离心


客观的。之前大多数关于无人机血液样本运输的研究都检查了在安静空气条件下运输的正常血液样本。我们使用随机振动和湍流模拟（10-30 克力）研究了 1 小时和 2 小时无人机飞行对 16 名健康志愿者和 74 名患有不同疾病的患者的血液样本的影响。方法：测试了 32 种最常见的分析物。对于生化分析物，我们使用在带有或不带有分离凝胶的肝素锂管中收集的血浆。分析凝胶样品在湍流之前或之后通过离心分离的效果。使用随机振动（范围，5-200 Hz）在 LDS V8900 高力振动台中模拟湍流，将样本随机分配到 1 或 2 小时的飞行中，并在 10 至 30 G 范围内发生 25 或 50 次湍流。结果：对于所有血液分析物和大多数生化分析物，湍流暴露前后的测试结果相似（偏差 < 12%，截距 < 10%）。然而，在振动和湍流测试之前通过凝胶和离心分离的样品中天冬氨酸转氨酶、叶酸、乳酸脱氢酶和脂质指数显着增加。这些变化从 10 G 增加到 30 G，但在振动和湍流后分离样品时没有观察到。结论：全血几乎不受湍流影响，而通过凝胶与血细胞分离的血浆样品在暴露前通过旋转分离时可能会受到湍流的显着影响。在可能受到湍流的无人机飞行之前，应避免对装有分离胶的管中收集的血浆样本进行离心。