In the era of antimicrobial resistance, fungal pathogens are not an exception. Several strategies, including antimicrobial stewardship programs and high throughput screening of new drugs, are being implemented. Several recent studies have demonstrated the effectiveness of plant compounds with antifungal activity. In this systematic review, we examine the use of natural compounds as a possible avenue to fight fungal infections produced by Candida albicans, the most common human fungal pathogen. Electronic literature searches were conducted through PubMed/MEDLINE, Cochrane, and Science Direct limited to the 5 years. A total of 131 articles were included, with 186 plants extracts evaluated. Although the majority of the natural extracts exhibited antifungal activities against C. albicans (both in vivo and in vitro), the strongest antifungal activity was obtained from Lawsonia inermis, Pelargonium graveolens, Camellia sinensis, Mentha piperita, and Citrus latifolia. The main components with proven antifungal activities were phenolic compounds such as gallic acid, thymol, and flavonoids (especially catechin), polyphenols such as tannins, terpenoids and saponins. The incorporation of nanotechnology greatly enhances the antifungal properties of these natural compounds. Further research is needed to fully characterize the composition of all herbal extracts with antifungal activity as well as the mechanisms of action of the active compounds.

在抗菌素耐药的时代，真菌病原体也不例外。目前正在实施几种策略，包括抗菌素管理计划和高通量新药筛查。最近的一些研究证明了具有抗真菌活性的植物化合物的有效性。在本系统综述中，我们研究了使用天然化合物作为对抗白色念珠菌（最常见的人类真菌病原体）产生的真菌感染的可能途径。电子文献检索是通过PubMed / MEDLINE，Cochrane和Science Direct进行的，限于5年。总共包括131篇文章，评估了186种植物提取物。尽管大多数天然提取物均对白色念珠菌具有抗真菌活性（无论是体内还是体外），最强的抗真菌活性是从无草紫花香，天竺葵，山茶，薄荷和柑桔中获得的。具有证明的抗真菌活性的主要成分是酚类化合物，例如没食子酸，百里酚和黄酮类化合物（尤其是儿茶素），多酚例如丹宁酸，萜类化合物和皂苷。纳米技术的引入大大增强了这些天然化合物的抗真菌性能。需要进一步研究以充分表征具有抗真菌活性的所有草药提取物的组成以及活性化合物的作用机理。和类黄酮（尤其是儿茶素），多酚（例如丹宁，萜类和皂苷）。纳米技术的引入大大增强了这些天然化合物的抗真菌性能。需要进一步研究以充分表征具有抗真菌活性的所有草药提取物的组成以及活性化合物的作用机理。和类黄酮（尤其是儿茶素），多酚（例如丹宁，萜类和皂苷）。纳米技术的引入大大增强了这些天然化合物的抗真菌性能。需要进一步研究以充分表征具有抗真菌活性的所有草药提取物的组成以及活性化合物的作用机理。