In this study, we have investigated the effect of adding zinc chloride (ZnCl₂) on polycaprolactone (PCL) before and after electrospinning. The rheological properties and conductivity of ZnCl₂/PCL solutions were measured prior to the electrospinning process. The resultant electrospun mats were characterized by SEM, contact angle, FTIR, XRD, mechanical properties, as well as its antibacterial and stem cell proliferation assessment were tested. It was found that the fibers became finer by increasing the zinc salt content. Moreover, stability increased slightly up to 5% Zn-PCL and also the hydrophilicity has been enhanced by 52%. By adding ZnCl₂, the degradation rate and mechanical properties were significantly increased. Also, the resultant mats have shown antibacterial properties against S. aureus than E. coli. From the stem cells proliferation study, it can be observed that by increasing ZnCl₂, the stem cells proliferation was significantly increased. Grooved multichannel nerve conduits were successfully fabricated by rolling the electrospun mats produced on corn husks which has shown better cell alignment and attachment. Hence, adding zinc chloride is a facile biocompatible enhancement to polycaprolactone nanofibers to be used in nerve regeneration.

在这项研究中，我们研究了在静电纺丝前后添加氯化锌（ZnCl ₂）对聚己内酯（PCL）的影响。在电纺丝之前先测量ZnCl ₂ / PCL溶液的流变性能和电导率。通过SEM，接触角，FTIR，XRD，机械性能以及对它的抗菌和干细胞增殖评估，对所得的电纺垫进行了表征。发现通过增加锌盐含量，纤维变得更细。此外，在5％Zn-PCL的作用下，稳定性略有提高，亲水性也提高了52％。通过添加ZnCl ₂，降解率和机械性能均明显提高。而且，所得的垫子还显示出比大肠杆菌更具有针对金黄色葡萄球菌的抗菌性能。从干细胞增殖研究中可以看出，通过增加ZnCl ₂，干细胞增殖显着增加。通过滚动在玉米皮上产生的电纺垫成功地制造了带凹槽的多通道神经导管，该电纺垫具有更好的细胞排列和附着性。因此，添加氯化锌是对用于神经再生的聚己内酯纳米纤维的便捷的生物相容性增强。