This study aimed to evaluate the effect of sleep duration on brain structures in the presence versus absence of sleep apnea in middle-aged and older individuals. The study investigated a population-based sample of 2,560 individuals, aged 49-80 years. The presence of sleep apnea and self-reported sleep duration were examined in relation to gray matter volume (GMV) in total and lobar brain regions. We identified ranges of sleep duration associated with maximal GMV using quadratic regression and bootstrap sampling. A significant quadratic association between sleep duration and GMV was observed in total and lobar brain regions of men with sleep apnea. In the fully adjusted model, optimal sleep durations associated with peak GMV between brain regions ranged from 6.7 to 7.0 hours. Shorter and longer sleep durations were associated with lower GMV in total and 4 sub-regions of the brain in men with sleep apnea.

本研究旨在评估中老年人在存在与不存在睡眠呼吸暂停的情况下睡眠持续时间对大脑结构的影响。该研究调查了 2,560 名年龄在 49-80 岁之间的人群样本。睡眠呼吸暂停的存在和自我报告的睡眠持续时间与总和脑叶区域的灰质体积 (GMV) 的关系进行了检查。我们使用二次回归和引导抽样确定了与最大 GMV 相关的睡眠持续时间范围。在患有睡眠呼吸暂停的男性的总脑区和大叶脑区观察到睡眠持续时间和 GMV 之间存在显着的二次关联。在完全调整的模型中，与大脑区域之间的峰值 GMV 相关的最佳睡眠持续时间为 6.7 至 7.0 小时。