A 50 × 50 × 10 mm³ monolithic gadolinium aluminum gallium garnet (Gd₃Al₂Ga₃O₁₂; GAGG):Ce crystal coupled to a 8 × 8 silicon photomultiplier (SiPM) array was developed; it showed very good system uniformity and a high energy resolution of 7.4% at 662 keV. By using a convolutional neural network-based positioning algorithm and a fan-beam calibration method, the detector achieved a position resolution of ∼1.4 mm and a depth of interaction resolution of ∼2 mm. Based on this high-performance monolithic detector, we developed a coded aperture gamma camera. A 1-mCi Cs-137 source centered at a 2-m distance from the mask could be reconstructed with a signal-to-noise ratio of 6.5 in 1 s. Furthermore, the imaging ability of a low-energy Am-241 source and a low-activity Cs-137 source when the background-to-signal ratio was approximately 1:1 and a double low-activity source (Cs-137 and Na-22) was demonstrated. It is shown that the monolithic-crystal-based coded aperture gamma camera can achieve high performance and has a large potential for further improvement.

中文翻译：

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基于单片GAGG：Ce晶体的高性能编码孔径伽马相机

50×50×10 mm ³单片ado铝镓石榴石（Gd ₃ Al ₂ Ga ₃ O ₁₂; GAGG）：开发了耦合到8×8硅光电倍增管（SiPM）阵列的Ce晶体；它显示出非常好的系统均匀性，在662 keV下的能量分辨率为7.4％。通过使用基于卷积神经网络的定位算法和扇形光束校准方法，该探测器的位置分辨率约为1.4 mm，相互作用深度分辨率约为2 mm。基于这种高性能的整体探测器，我们开发了一种编码孔径伽马相机。可以重建1 mCi Cs-137源，其中心距离掩模2 m的距离，其信噪比在1 s内为6.5。此外，当背景信号比约为1：1时，低能Am-241源和低活性Cs-137源的成像能力以及双重低活性源（Cs-137和Na- 22）进行了演示。