A number of different laboratory procedures investigate the hormonal response in a standardized pharmacological challenge test (dexamethasone‐corticotropin releasing hormone; DEX‐CRH) or in a psychosocial stress induction on the hypothalamic–pituitary–adrenocortical axis by the Trier Social Stress Test (TSST). However, the magnitude of the response related to the different stressors and the interaction of the responsiveness between the two tests is still unclear. Fifty‐two participants underwent both the DEX‐CRH test and the TSST on two separate days. The cortisol and the plasma adrenocorticotropic hormone (ACTH) release were assessed before and after the stress tests. For a specification of the cortisol response to both conditions, subgroups of high‐ and low‐cortisol responders to the TSST and the DEX‐CRH test were formed. The healthy participants showed a substantial increase in the ACTH and the cortisol concentration after the two tests. This increase was 3 times greater in the TSST than the DEX‐CRH test. High responders in both tests demonstrated a higher factor of the cortisol reactivity ratio (TSST/DEX‐CRH test). Psychosocial stress as induced by the TSST was associated with a significantly greater increase in cortisol compared to the DEX‐CRH test, even though the ACTH response displayed no differences. Our findings indicate an interaction of the hormonal responsiveness between the two tests with regard to the cortisol patterns.

中文翻译：

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健康人的特里尔社会压力测试和地塞米松-促肾上腺皮质激素释放激素测试中的激素反应

许多不同的实验室程序通过标准的药理学挑战试验（地塞米松-促肾上腺皮质激素释放激素； DEX-CRH）或通过特里尔社会压力测试（TSST）在下丘脑-垂体-肾上腺皮质轴的心理社会压力诱导中研究激素反应。 。但是，与不同压力源相关的响应强度以及两个测试之间的响应性相互作用尚不清楚。52位参与者分别在两天内接受了DEX-CRH测试和TSST测试。在压力测试之前和之后评估皮质醇和血浆促肾上腺皮质激素（ACTH）的释放。为了规范对两种情况的皮质醇反应，形成了对TSST和DEX-CRH测试的高皮质醇和低皮质醇反应者亚组。健康的参与者在两次测试后显示出ACTH和皮质醇浓度的显着增加。TSST的增加量是DEX-CRH测试的3倍。两项测试中的高响应者均显示出较高的皮质醇反应率因子（TSST / DEX-CRH测试）。尽管ACTH反应没有差异，但与DEX-CRH试验相比，由TSST引起的社会心理压力与皮质醇的明显增加有关。我们的发现表明，两种测试之间关于皮质醇模式的激素反应性之间存在相互作用。两项测试中的高响应者均显示出较高的皮质醇反应率因子（TSST / DEX-CRH测试）。尽管ACTH反应没有差异，但与DEX-CRH试验相比，由TSST引起的社会心理压力与皮质醇的明显增加有关。我们的发现表明，两种测试之间关于皮质醇模式的激素反应性之间存在相互作用。两项测试中的高响应者均显示出较高的皮质醇反应率因子（TSST / DEX-CRH测试）。尽管ACTH反应没有差异，但与DEX-CRH试验相比，由TSST引起的社会心理压力与皮质醇的明显增加有关。我们的发现表明，两种测试之间关于皮质醇模式的激素反应性之间存在相互作用。