Purpose

To compare the electrophysiology between mild thyroid-associated ophthalmopathy (TAO) patients and normal population.

Methods

The present research was a retrospective observational study and enrolled consecutive patients diagnosed with mild TAO according to European Group on Graves’s Orbitopathy with corrected to normal vision. Full-field electroretinography, pattern visual evoked potential (PVEP) and isolated-check visual evoked potential (icVEP) were performed for TAO patients and age-matched normal subjects.

Results

Thirty-two eyes with mild TAO and forty-six eyes from normal subjects were included. Statistically significant increase in the amplitude of dark-adapted 0.01, 3 and 10 ERG and total oscillatory potentials and light-adapted 3 and 30 Hz flicker ERG were observed in TAO patients compared with the normal subjects, but not the latency. No significant difference was observed in the P100 amplitude or latency in 1° and 15′ PVEP between TAO patients and normal subjects. The signal-to-noise ratio (SNR) was not significantly different in TAO patients at the contrast of 1%, 2%, 8%, 16% or 32% icVEP, and the SNR in contrast 4% icVEP was significantly smaller in TAO patients compared to normal subjects.

Conclusion

Mild TAO patients can have electrophysiological changes that might indicate neural changes in the early disease phase.

中文翻译：

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电生理检查在早期甲状腺相关眼病评估中的应用

目的

比较轻度甲状腺相关眼病（TAO）患者与正常人群的电生理。

方法

本研究是一项回顾性观察研究，纳入了根据欧洲 Graves 眼眶病组诊断为轻度 TAO 且视力矫正正常的连续患者。对 TAO 患者和年龄匹配的正常受试者进行全视野视网膜电图、模式视觉诱发电位 (PVEP) 和孤立检查视觉诱发电位 (icVEP)。

结果

包括轻度 TAO 的 32 只眼睛和正常受试者的 46 只眼睛。与正常受试者相比，在 TAO 患者中观察到暗适应 0.01、3 和 10 ERG 的幅度和总振荡电位以及光适应的 3 和 30 Hz 闪烁 ERG 的幅度在统计学上显着增加，但没有观察到潜伏期。在 TAO 患者和正常受试者之间，1°和 15' PVEP 的 P100 幅度或潜伏期没有观察到显着差异。1%、2%、8%、16%或32% icVEP对比下TAO患者的信噪比(SNR)无显着差异，TAO对比4% icVEP的SNR显着较小患者与正常人相比。

结论

轻度 TAO 患者可能有电生理变化，这可能表明疾病早期阶段的神经变化。