Cardiovascular pathologies are often induced by inflammation. The associated changes in the inflammatory response influence vascular endothelial biology; they complicate the extent of ischaemia and reperfusion injury, direct the migration of immune competent cells and activate platelets. The initiation and progression of inflammation is regulated by the classical paradigm through the system of cytokines and chemokines. Therapeutic approaches have previously used this knowledge to control the extent of cardiovascular changes with varying degrees of success. Neuronal guidance proteins (NGPs) have emerged in recent years and have been shown to be significantly involved in the control of tissue inflammation and the mechanisms of immune cell activation. Therefore, proteins of this class might be used in the future as targets to control the extent of inflammation in the cardiovascular system. In this review, we describe the role of NGPs during cardiovascular inflammation and highlight potential therapeutic options that could be explored in the future.

心血管疾病通常由炎症引起。炎症反应的相关变化影响血管内皮生物学；它们使缺血和再灌注损伤的程度复杂化，指导免疫活性细胞的迁移并激活血小板。炎症的发生和进展受经典范式通过细胞因子和趋化因子系统调节。治疗方法以前使用这些知识来控制心血管变化的程度，并取得了不同程度的成功。近年来出现了神经元引导蛋白（NGPs），并已被证明与组织炎症的控制和免疫细胞激活机制密切相关。所以，这类蛋白质将来可能被用作控制心血管系统炎症程度的靶点。在这篇综述中，我们描述了 NGP 在心血管炎症中的作用，并强调了未来可以探索的潜在治疗选择。