Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased which is defined as decreased ability of the testes to produce sperm and sex steroids because of a pituitary/hypothalamic, or testicular deficiency. In academic andrology associations, the term "male hypogonadism" is commonly used to categorize testosterone deficiency. Testosterone deficiency syndrome (TDS) is defined as a decrease in serum testosterone accompanied by symptoms such as libido decrease, depressive disorder, erectile dysfunction, and fatigue. Although the mechanism about testosterone-replacement therapy (TRT) effects on men with hypogonadism is not yet identified, TRT has been shown to effectively relieve the symptoms of TDS as well as LUTS by several studies. Although the present review demonstrates the effectiveness and safety of TRT in men with TDS by prior studies, future large scale of clinical trials should be conducted to present more high-quality evidence to clinicians and patients.

中文翻译：

---

睾丸激素替代治疗与下尿路症状之间的相关性。

下尿路症状（LUTS）是一排排尿症状，例如弱流，犹豫，间断，尿频，尿急和夜尿。LUTS在老年男性中很常见，被认为是前列腺增生的最终临床症状。随着年龄的增长，男性性腺功能减退症增加，其定义为由于垂体/下丘脑或睾丸缺乏导致睾丸产生精子和性类固醇的能力降低。在学术男科学协会中，术语“男性性腺机能减退”通常用于对睾丸激素缺乏症进行分类。睾丸激素缺乏综合征（TDS）的定义是血清睾丸激素水平降低，并伴有性欲降低，抑郁症，勃起功能障碍和疲劳等症状。尽管尚未确定有关性腺功能减退男性睾丸激素替代疗法（TRT）作用的机制，但多项研究显示TRT可以有效缓解TDS和LUTS的症状。尽管本综述通过先前的研究证明了TRT在患有TDS的男性中的有效性和安全性，但仍应进行未来的大规模临床试验，以向临床医生和患者提供更多高质量的证据。