To date, there has been no effective treatment for intervertebral disc degeneration (IDD). Nucleus pulposus-derived mesenchymal stem cells (NPMSCs) showed encouraging results in IDD treatment, but the overexpression of reactive oxygen species (ROS) impaired the endogenous repair abilities of NPMSCs. 6-gingerol (6-GIN) is an antioxidant and anti-inflammatory reagent that might protect NPMSCs from injury.

中文翻译：

---

6-姜油酚通过激活自噬保护髓核来源的间充质干细胞免受氧化损伤。

迄今为止，还没有有效的椎间盘退变（IDD）治疗方法。髓核来源的间充质干细胞（NPMSCs）在IDD治疗中显示出令人鼓舞的结果，但活性氧（ROS）的过表达损害了NPMSCs的内源性修复能力。6-姜油酚（6-GIN）是一种抗氧化剂和抗炎药，可以保护NPMSC免受伤害。