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Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells.
World Journal of Stem Cells ( IF 3.6 ) Pub Date : 2021-1-29 , DOI: 10.4252/wjsc.v12.i12.1640
Cintia DS Horinouchi , María Julia Barisón , Anny W Robert , Crisciele Kuligovski , Alessandra M Aguiar , Bruno Dallagiovanna

Human adipose-derived stromal/stem cells (hASCs) are one of the most useful types of mesenchymal stromal/stem cells, which are adult multipotent cells with great therapeutic potential for the treatment of several diseases. However, for successful clinical application, it is critical that high-quality cells can be obtained. Diverse factors seem to be able to influence cell quality and performance, especially factors related to donors' intrinsic characteristics, such as age. Nevertheless, there is no consensus regarding this characteristic, and there is conflicting information in the literature.

中文翻译:

供体年龄对人脂肪干细胞分化和分裂能力的影响。

人脂肪来源的基质/干细胞(hASCs)是间充质基质/干细胞最有用的类型之一,它们是成年的多能细胞,具有治疗多种疾病的巨大治疗潜力。然而,对于成功的临床应用而言,获得高质量细胞至关重要。多种因素似乎能够影响细胞的质量和性能,尤其是与供体固有特征(例如年龄)有关的因素。然而,关于这一特征尚无共识,并且文献中存在相互矛盾的信息。
更新日期:2021-01-30
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