### Summary box #### What are the new findings? #### How might it impact on healthcare in the future? It is more than 100 years since the blood–brain barrier was discovered.1 The blood–brain barrier protects the brain from external agents. But this natural protection also prevents 98% of the small drugs and 100% of the large drugs available today from entering the brain in concentrations that can produce the required therapeutic effects.2 In Parkinson’s disease, focus is currently on techniques to effect continuous tonic firing of diseased dopamine neurons as in normal physiologic conditions. But dopamine does not cross the blood–brain barrier normally. In Alzheimer’s disease, focus is currently on immunotherapy. But, the entry of the peripherally administered antibodies into the brain has been limited to around 0.1%–0.2% by the blood–brain barrier. In tumours involving the brainstem, the prognosis has been poor because drug delivery is restricted by the blood–brain barrier. In the eye, retinal drug delivery is a challenge till date because of the blood retinal barrier. This study assesses the efficacy of a novel oral and maxillofacial device and technique for delivering drugs into the brain. This technique also provides access to the optic nerve and vessels and therefore can deliver drugs into the retina and the vitreous. The device is implanted in the oral or maxillofacial region and the drugs are delivered directly into the connective tissue of the respiratory mucosa of the maxillary sinus, from where the drugs get …

中文翻译：

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用于控制和连续向大脑输送药物的新技术和设备：概念验证研究

###摘要框####有哪些新发现？####将来对医疗保健有何影响？自发现血脑屏障以来已有100多年的历史。1血脑屏障可保护大脑免受外部因素的侵害。但是，这种自然保护作用还可以防止当今可用的98％的小药和100％的大药进入大脑，其浓度可产生所需的治疗效果。2在帕金森氏病中，目前的重点是持续补药射击的技术。正常生理状况下患病的多巴胺神经元的数量。但是多巴胺通常不会穿过血脑屏障。在阿尔茨海默氏病中，目前的重点是免疫疗法。但是，外围施用的抗体进入大脑的限制在0.1％-0之间。血脑屏障占2％。在涉及脑干的肿瘤中，预后很差，因为药物的输送受到血脑屏障的限制。在眼中，由于血液的视网膜屏障，视网膜药物的递送一直是一个挑战。这项研究评估了新型口服和颌面装置和技术将药物输送到大脑的功效。该技术还提供了通向视神经和血管的通道，因此可以将药物输送到视网膜和玻璃体中。该设备被植入口腔或颌面部区域，药物被直接输送到上颌窦呼吸道粘膜的结缔组织中，药物从那里到达…… 迄今为止，由于血液中的视网膜屏障，视网膜药物的递送一直是一个挑战。这项研究评估了新型口服和颌面装置和技术将药物输送到大脑的功效。该技术还提供了通向视神经和血管的通道，因此可以将药物输送到视网膜和玻璃体中。该设备被植入口腔或颌面部区域，药物被直接输送到上颌窦呼吸道粘膜的结缔组织中，药物从那里到达…… 迄今为止，由于血液中的视网膜屏障，视网膜药物的递送一直是一个挑战。这项研究评估了新型口服和颌面装置和技术将药物输送到大脑的功效。该技术还提供了通向视神经和血管的通道，因此可以将药物输送到视网膜和玻璃体中。该设备被植入口腔或颌面部区域，药物被直接输送到上颌窦呼吸道粘膜的结缔组织中，药物从那里到达…… 该技术还提供了通向视神经和血管的通道，因此可以将药物输送到视网膜和玻璃体中。该设备被植入口腔或颌面部区域，药物被直接输送到上颌窦呼吸道粘膜的结缔组织中，药物从那里到达…… 该技术还提供了通向视神经和血管的通道，因此可以将药物输送到视网膜和玻璃体中。该设备被植入口腔或颌面部区域，药物被直接输送到上颌窦呼吸道粘膜的结缔组织中，药物从那里到达……