Background: The metabolic syndrome (MetS) represents a clustering of risk factors for cardiovascular diseases that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance. Objectives: The objective of this study was to reassess the parent-offspring association of MetS since the available findings are still controversial. Methods: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All studies comparing MetS status between the offspring of parents with MetS and offspring of parents without MetS were included in the analysis. Results: A total of 9 studies met the inclusion criteria and they were analyzed. Offspring of at least 1 parent with MetS had a higher risk of MetS (OR 3.88, 95% CI 2.58–5.83, p #x3c; 0.001). Sons and daughters of fathers with MetS both had a higher risk of MetS (OR 2.31, 95% CI 1.70–3.12, p #x3c; 0.001, and OR 1.73, 95% CI 1.37–2.18, p #x3c; 0.001, respectively). Sons and daughters of mothers with MetS both had a higher risk of MetS (OR 1.95, 95% CI 1.37–2.76, p = 0.0002, and OR 1.91, 95% CI 1.54–2.35, p #x3c; 0.001, respectively). Conclusion: This meta-analysis showed that there is a higher risk of MetS in the offspring of parents with MetS. However, there was no differential association of MetS according to gender and/or age of the offspring.
Obes Facts

中文翻译：

---

代谢综合征父母后代的代谢综合征：荟萃分析

背景：代谢综合症（MetS）代表了心血管疾病的风险因素，包括腹部肥胖，高血压，血脂异常和胰岛素抵抗。目的：这项研究的目的是重新评估MetS的亲子关系，因为现有的发现仍然存在争议。方法：搜索Cochrane图书馆，PubMed，Embase和Web of Science数据库，以鉴定相关文章。分析中包括所有比较有MetS的父母的后代与没有MetS的父母的后代之间的MetS状况的研究。结果：共有9项研究符合纳入标准，并进行了分析。至少1名患有MetS的父母的后代具有更高的MetS风险（OR 3.88，95％CI 2.58–5.83，p＃x3c； 0.001）。患有MetS的父亲的儿子和女儿均具有较高的MetS风险（OR为2.31，95％CI为1.70-3.12，p＃x3c； 0.001； OR 1.73，95％CI为1.37-2.18，p＃x3c； 0.001） 。患有MetS的母亲的子女均具有较高的MetS风险（OR 1.95，95％CI 1.37-2.76，p = 0.0002，OR 1.91，95％CI 1.54-2.35，p＃x3c； 0.001）。结论：这项荟萃分析表明，患有MetS的父母的后代有较高的MetS风险。然而，根据后代的性别和/或年龄，MetS没有差异关联。
肥胖事实