Psychiatric symptoms in children with Fetal Alcohol Spectrum Disorders (FASD) present with high prevalence and morbidity, often across symptom domains, e.g. ADHD-like symptoms, emotional dysregulation and sleep problems. Polypharmacy is often used, but no empirically-based guidelines exist regarding optimal treatment for these children. Moreover, stimulant use in these children is controversial as their responsiveness may be different due to altered neural circuitry associated with prenatal alcohol exposure. The objective of this review is to give an overview of existing data on pharmacological treatments of neurobehavioral symptoms in FASD. Our literature review yielded limited and conflicting clinical data on the effectiveness of pharmacological treatments for psychiatric symptoms in children with FASD, with some symptom domains lacking data altogether. We emphasize the need for clinical trials to guide pharmacological treatments in this complex population.

胎儿酒精谱系障碍 (FASD) 儿童的精神症状具有较高的患病率和发病率，通常跨越症状领域，例如多动症样症状、情绪失调和睡眠问题。经常使用多种药物，但没有关于这些儿童的最佳治疗的基于经验的指南。此外，这些儿童使用兴奋剂是有争议的，因为由于产前酒精暴露相关的神经回路改变，他们的反应可能有所不同。本综述的目的是概述 FASD 神经行为症状药物治疗的现有数据。我们的文献综述得出了关于药物治疗 FASD 儿童精神症状有效性的有限且相互矛盾的临床数据，其中一些症状领域完全缺乏数据。我们强调需要进行临床试验来指导这一复杂人群的药物治疗。