Abstract

2,3-Dihydro-2-oxo-4-phenyl-6-(thien-2-yl)pyridine-3-carbonitrile (4) was synthesized via reaction of four compounds (benzaldehyde, 2-acetylthiophene, ethyl cyanoacetate and ammonium acetate) in one step reaction. 2-((Hydrazinocarbonyl)methyloxy)-4-phenyl-6-(2-thienyl)pyridine-3-carbonitrile was obtained by reaction of 5 with hydrazine hydrate. Schiff’s bases, pyrazole derivatives, urea derivatives, and carbamates were also synthesized. Based on the spectral facts and elemental analysis, structures of the newly synthesized compounds were elucidated. Also, the new compounds were evaluated for their antibacterial and antitumor activities.

摘要

通过四种化合物（苯甲醛，2-乙酰基噻吩，氰基乙酸乙酯和乙酸铵）的反应合成了2,3-二氢-2-氧代-4-苯基-6-（噻吩-2-基）吡啶-3-腈（4））一步反应。通过使5与水合肼反应获得2-（（肼基羰基）甲氧基）-4-苯基-6-（2-噻吩基）吡啶-3-甲腈。还合成了席夫氏碱，吡唑衍生物，尿素衍生物和氨基甲酸酯。基于光谱事实和元素分析，阐明了新合成的化合物的结构。同样，评估了新化合物的抗菌和抗肿瘤活性。