Abstract

Objective

We undertook the present study to investigate the cognitive status of patients with interstitial lung disease (ILD) and its relationship to pulmonary function and cardiovascular efficiency.

Method

Fifty-one patients with a diagnosis of ILD [mean duration = 3.13 years (SD = 3.01)] received a respiratory examination, including spirometry and the six-minute walk test, and completed a neuropsychological assessment including several cognitive domains. Eighty-eight healthy individuals matched on age, education, and gender, completed the neuropsychological test battery.

Results

Patients performed more poorly than their healthy peers on cognitive tasks related to verbal and visual memory, visual perception, and working memory, but not attention, processing speed and executive functioning. Stepwise linear regression analyses showed that exercise-related measures (heart rate, oxygen saturation and distance walked) predicted performance on neuropsychological tests of psychomotor speed, verbal memory and word production. Additionally, an index of pulmonary function, specifically, lung diffusion capacity, predicted performance on selective and sustained attention and word generation.

Conclusion

The present preliminary findings may have implications for the quality of life and treatment compliance of patients with ILD and warrant further study with a larger sample of patients.

中文翻译：

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间质性肺疾病患者的神经心理功能

摘要

目的

我们进行了本研究，以调查间质性肺病（ILD）患者的认知状况及其与肺功能和心血管效率的关系。

方法

51名诊断为ILD的患者[平均病程= 3.13年（SD  = 3.01）]接受了呼吸检查，包括肺活量测定和六分钟步行测试，并完成了包括几个认知领域的神经心理学评估。88名年龄，文化程度和性别相匹配的健康个体完成了神经心理学测试。

结果

在与言语和视觉记忆，视觉知觉和工作记忆有关的认知任务上，患者的表现比健康同伴差，但在注意力，处理速度和执行功能上却没有。逐步线性回归分析显示，与运动有关的测量（心率，血氧饱和度和步行距离）可以预测心理运动速度，言语记忆和单词产生的神经心理学测试的表现。另外，肺功能的指标，特别是肺扩散能力，可以预测选择性和持续注意力以及单词生成的表现。

结论

目前的初步发现可能对ILD患者的生活质量和治疗依从性有影响，需要对更多的患者样本进行进一步研究。