The critical roles played by advanced glycation endproducts (AGEs) accumulation in diabetes and diabetic complications have gained intense recognition. AGEs interfere with the normal functioning of almost every organ with multiple actions like apoptosis, inflammation, protein dysfunction, mitochondrial dysfunction, and oxidative stress. However, the development of a potential treatment strategy is yet to be established. Autophagy is an evolutionarily conserved cellular process that maintains cellular homeostasis with the degradation and recycling systems. AGEs can activate autophagy signaling, which could be targeted as a therapeutic strategy against AGEs induced problems. In this review, we have provided an overview of the adverse effects of AGEs, and we put forth the notion that autophagy could be a promising targetable strategy against AGEs.

中文翻译：

---

晚期糖基化终产物及其不利影响：自噬的作用

晚期糖基化终产物（AGEs）积累在糖尿病和糖尿病并发症中所起的关键作用已得到广泛认可。AGEs会通过凋亡，炎症，蛋白质功能异常，线粒体功能异常和氧化应激等多种作用干扰几乎每个器官的正常功能。但是，尚未建立潜在的治疗策略。自噬是一种进化上保守的细胞过程，可通过降解和再循环系统维持细胞稳态。AGEs可以激活自噬信号传导，这可以作为针对AGEs诱导的问题的治疗策略。在这篇综述中，我们对AGEs的不利影响进行了概述，并提出了自噬可能是针对AGEs的有希望的靶向策略的观点。