Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.

中文翻译：

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中性粒细胞为转移创造了肥沃的土壤

中性粒细胞可以促进癌症的转移扩散；然而，中性粒细胞如何在转移部位被激活仍然知之甚少。在这个问题上，肖等人。证明由乳腺癌细胞分泌的蛋白酶组织蛋白酶 C 触发中性粒细胞在转移性生态位中形成中性粒细胞胞外陷阱，从而促进肺转移。