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Amino BODIPY-Based Blue Fluorescent Probes for Aldehyde Dehydrogenase 1-Expressing Cells
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-01-27 , DOI: 10.1021/acs.bioconjchem.0c00565
Atsushi Yagishita 1 , Tasuku Ueno , Katsuya Tsuchihara 2 , Yasuteru Urano
Affiliation  

Aldehyde dehydrogenase 1 (ALDH1) plays an important role as a stem cell marker. In the field of stem cell biology, a green fluorescent ALDH1 probe has been principally used, but there is a need for more options in probe color. We designed and synthesized two blue fluorescent ALDH1 probes using 8-amino BODIPY and aminomethylbenzaldehyde. These probes can be simultaneously used with other color probes. Here, we demonstrate successful examples of the simultaneous use of these probes with green fluorescent protein.

中文翻译:

用于醛脱氢酶 1 表达细胞的基于氨基 BODIPY 的蓝色荧光探针

醛脱氢酶 1 (ALDH1) 作为干细胞标记物发挥着重要作用。在干细胞生物学领域,主要使用的是绿色荧光ALDH1探针,但在探针颜色上还需要更多的选择。我们使用 8-氨基 BODIPY 和氨基甲基苯甲醛设计并合成了两种蓝色荧光 ALDH1 探针。这些探头可以与其他颜色探头同时使用。在这里,我们展示了同时使用这些探针与绿色荧光蛋白的成功例子。
更新日期:2021-02-17
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