Silver(I)‐mediated hetero base pairs of 6‐pyrazolylpurine and its deaza derivatives,Zeitschrift für anorganische und allgemeine Chemie

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Silver(I)‐mediated hetero base pairs of 6‐pyrazolylpurine and its deaza derivatives
Zeitschrift für anorganische und allgemeine Chemie ( IF 1.1 ) Pub Date : 2021-01-27 , DOI: 10.1002/zaac.202000481
Daniela Escher ₁ , Jens Müller ₂

Affiliation

A series of antiparallel‐stranded and parallel‐stranded DNA duplexes containing hetero base pairs of the artificial nucleobases 6‐(1H‐pyrazol‐1‐yl)‐9H‐purine (6PP), 1‐deaza‐6PP (^1D6PP), 7‐deaza‐6PP (^7D6PP), and 1,7‐dideaza‐6PP (^1,7D6PP) were investigated with respect to their ability to form silver(I)‐mediated base pairs. A close examination of the duplex melting temperatures in the absence and in the presence of silver(I) ions shows a strong sequence‐dependence of the stability of the resulting silver(I)‐mediated base pairs. The most stable silver(I)‐mediated base pairs are formed when ^1,7D6PP is located in a purine‐rich strand opposite either 6PP or ^7D6PP. This indicates that the silver(I) ions are coordinated via the Watson‐Crick edge of the latter nucleobase, whereas they bind to the pyrazolyl moiety of the former. As a result, a [2+1] coordination environment is proposed for the silver(I) ions.

中文翻译：

银（I）介导的6-吡唑基嘌呤及其deaza衍生物的杂碱基对

一系列的反平行链和平行链DNA双链体，包含人工核碱基6-（1 H-吡唑-1-基）-9 H-嘌呤（6PP），1-脱氮基-6PP（^1D 6PP）的杂碱基对分别研究了7-deaza-6PP（^7D 6PP）和1,7-dideaza-6PP（^1,7D 6PP）形成银（I）介导的碱基对的能力。在不存在和存在银（I）离子的情况下，仔细检查双链体的熔化温度可发现所得银（I）介导的碱基对的稳定性与序列的依赖性很大。当^1,7D 6PP位于与6PP或^7D相对的富嘌呤链中时，形成最稳定的银（I）介导的碱基对6PP。这表明银（I）离子通过后者核碱基的沃森-克里克边进行配位，而它们与前者的吡唑基部分结合。结果，提出了银（I）离子的[2 + 1]配位环境。

更新日期：2021-03-11

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