Sulfoxide hemithioindigo tweezers – visible light addressable capture and release,Chemical Science

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Sulfoxide hemithioindigo tweezers – visible light addressable capture and release
Chemical Science ( IF 7.6 ) Pub Date : 2021-1-14 , DOI: 10.1039/d0sc04981f
Thomas Bartelmann ₁ , Frederik Gnannt ₂ , Max Zitzmann ₂ , Peter Mayer ₁ , Henry Dube _{1,

2}

Affiliation

Introducing responsive elements into supramolecular recognition systems offers great advantages for the control of intermolecular interactions and represents an important stepping stone towards multi-purpose and reprogrammable synthetic systems. Of particular interest is implementation of light-responsiveness because of the unique ease and precision of this signal. Here we present visible light responsive hemithioindigo-based molecular tweezers that bear a highly polar sulfoxide function as an additional recognition unit inside their binding site. Sulfur oxidation allows to simultaneously enhance all crucial properties of this receptor type i.e. photoswitching capability, thermal stability of individual switching states, binding affinity, and binding modulation upon switching. With a novel titration method the thermodynamic binding parameters were determined using reduced sample amounts. Employing these strongly enhanced molecular tweezers allowed to demonstrate photocontrol of intermolecular charge transfer in a reversible manner.

中文翻译：

亚砜半硫靛蓝镊子–可见光可寻址的捕获和释放

将响应元件引入超分子识别系统为控制分子间相互作用提供了巨大优势，并且代表了迈向多功能和可重编程合成系统的重要踏脚石。由于该信号独特的简便性和精确性，因此特别需要实现光响应性。在这里，我们介绍可见光响应的基于半硫靛蓝的分子镊子，其具有高极性的亚砜功能，作为其结合位点内的附加识别单元。硫氧化可同时增强该受体类型的所有关键特性，即光电开关功能，单个开关状态的热稳定性，结合亲和力和开关时的结合调制。使用新颖的滴定方法，可使用减少的样品量确定热力学结合参数。使用这些强烈增强的分子镊子可以以可逆的方式证明分子间电荷转移的光控制。

更新日期：2021-01-27

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