Microscopy is a basic and integral tool of health care and clinical medicine. It is not routinely available in health centers of rural and remote areas. Many individuals live in such resource-constrained locations with limited access to health care where fungal infections such as Candida albicans could be life-threatening. A smart mobile phone-based microscope like Foldscope has been used in this study to see its feasibility in a quick, easy, and cost-effective diagnosis of various infections. Foldscope is a simple, low cost, and portable device that supports inexpensive diagnostic testing in underserviced locations. We have used Foldscope to see the effect of some antifungal agent on an important human fungal pathogen C. albicans that causes the disease Candidiasis. Several molecules were screened in silico and Anthrone and l-asparagine were selected for further biochemical study based on their prominent results in molecular docking that was performed using the Schrodinger software licensed version 10.5, USA. Anthrone and l-asparagine have significant docking scores. So they were selected for further in vitro experimental analysis with the help of a Foldscope. We have determined the Minimum Inhibitory concentration (MIC) of Anthrone and l-asparagine against C. albicans for its antifungal therapeutic effect and they were further subjected to susceptibility testing. Morphological changes were observed and acquired by the Foldscope. The results obtained through Foldscope revealed that Anthrone and l-asparagine subsequently reduce hyphae formation in C. albicans. Overall results indicated that Foldscope holds promise for delivering low-cost laboratory-based technology to under-serviced locations and could be used for clinical investigation and public health care.

显微镜检查是保健和临床医学的基本和不可或缺的工具。农村和偏远地区的保健中心通常不提供这种药物。许多人生活在资源贫乏的地区，无法获得卫生保健，而真菌感染（例如白色念珠菌）可能危及生命。在这项研究中，使用了基于智能手机的显微镜（如Foldscope）来查看其在快速，轻松且经济高效地诊断各种感染中的可行性。Foldscope是一种简单，低成本且便携式的设备，可在服务不足的位置支持廉价的诊断测试。我们已经使用Foldscope来观察某些抗真菌剂对重要的人类真菌病原体白色念珠菌的作用导致疾病念珠菌病。在计算机上筛选了几个分子，并根据其在分子对接中的杰出结果选择了蒽酮和1-天冬酰胺，以进行进一步的生化研究，该结果是使用美国Schrodinger软件许可的10.5版进行的。蒽酮和1-天冬酰胺具有显着的对接分数。因此，借助Foldscope选择了它们进行进一步的体外实验分析。我们确定了蒽醌和1-天冬酰胺对白色念珠菌的最小抑制浓度（MIC）由于其具有抗真菌的治疗作用，因此对其进行了药敏试验。折叠镜观察并获得了形态学变化。通过Foldscope获得的结果表明，蒽酮和1-天冬酰胺随后减少了白色念珠菌中的菌丝形成。总体结果表明，Foldscope有望为服务不足的地点提供低成本的基于实验室的技术，并且可用于临床调查和公共卫生保健。