In this study, a temperature responsive PGS/[email protected] core-shell nanofiber membrane was prepared by combining electrospinning with surface ATRP grafting polymer technology, in which the core layer of PGS/PLLA nanofiber was prepared by electrospinning, and then the shell layer of temperature responsive PNIPAM polymer was grafted on the nanofiber surface by ATRP reaction. In the experiment, a macromolecule-initiator PGS-Br was prepared and characterized by FTIR and ¹H NMR. The surface morphology, composition, element of the core-shell nanofiber membrane were characterized by SEM, FTIR, and XPS. In addition, it is worth noting that the core-shell nanofiber membrane can respond to temperature in drug release tests.

在这项研究中，通过将电纺与表面ATRP接枝聚合物技术相结合，制备了具有温度响应性的PGS / [受电子邮件保护的]核壳纳米纤维膜，其中通过电纺制备了PGS / PLLA纳米纤维的核层，然后形成了壳层通过ATRP反应将温度敏感的PNIPAM聚合物接枝到纳米纤维表面。在实验中，制备了大分子引发剂PGS-Br，并通过FTIR和¹ H NMR对其进行了表征。通过SEM，FTIR和XPS对核-壳纳米纤维膜的表面形貌，组成和元素进行了表征。另外，值得注意的是，在药物释放测试中，核-壳纳米纤维膜可以对温度做出反应。