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Muscle Synergies in Patients With Multiple Sclerosis Reveal Demand-Specific Alterations in the Modular Organization of Locomotion
Frontiers in Human Neuroscience ( IF 2.4 ) Pub Date : 2021-01-27 , DOI: 10.3389/fnhum.2020.593365
Lars Janshen , Alessandro Santuz , Adamantios Arampatzis

For patients with multiple sclerosis (MS), deficits in gait significantly reduce the quality of life. Using the concept of muscle synergies, this study investigated the modular organization of motor control during level and inclined walking in MS patients (MSP) compared with healthy participants (HP) to identify the potential demand-specific adjustments in motor control in MSP. We hypothesized a widening of the time-dependent activation patterns (motor primitives) in MSP to increase the overlap of temporally-adjacent muscle synergies, especially during inclined walking, as a strategy to increase the robustness of motor control, thus compensating pathology-related deficits. We analyzed temporal gait parameters and muscle synergies from myoelectric signals of 13 ipsilateral leg muscles using non-negative matrix factorization. Compared with HP, MSP demonstrated a widening in the time-dependent coefficients (motor primitives), as well as altered relative muscle contribution (motor modules), in certain synergies during level and inclined walking. Moreover, inclined walking revealed a demand-specific adjustment in the modular organization in MSP, resulting in an extra synergy compared with HP. This further increased the overlap of temporally-adjacent muscle synergies to provide sufficient robustness in motor control to accomplish the more demanding motor task while coping with pathology-related motor deficits during walking.

中文翻译:

多发性硬化症患者的肌肉协同作用揭示了模块化运动组织的需求特定变化

对于多发性硬化症 (MS) 患者,步态缺陷会显着降低生活质量。使用肌肉协同的概念,本研究调查了 MS 患者 (MSP) 与健康参与者 (HP) 在水平和倾斜行走期间运动控制的模块化组织,以确定 MSP 中运动控制的潜在需求特定调整。我们假设 MSP 中时间依赖性激活模式(运动原语)的扩大以增加时间相邻肌肉协同作用的重叠,特别是在倾斜行走期间,作为一种增加运动控制鲁棒性的策略,从而补偿病理相关的缺陷. 我们使用非负矩阵分解分析了来自 13 条同侧腿部肌肉的肌电信号的时间步态参数和肌肉协同作用。与惠普相比,MSP 在水平和倾斜行走期间的某些协同作用中表现出时间相关系数(运动原语)的扩大,以及改变的相对肌肉贡献(运动模块)。此外,倾斜行走揭示了 MSP 中模块化组织的需求特定调整,与 HP 相比产生了额外的协同作用。这进一步增加了时间相邻肌肉协同作用的重叠,以提供足够的运动控制鲁棒性,以完成更苛刻的运动任务,同时应对行走过程中与病理相关的运动缺陷。倾斜行走揭示了 MSP 中模块化组织中针对特定需求的调整,与 HP 相比产生了额外的协同作用。这进一步增加了时间相邻肌肉协同作用的重叠,以提供足够的运动控制鲁棒性,以完成更苛刻的运动任务,同时应对行走过程中与病理相关的运动缺陷。倾斜行走揭示了 MSP 中模块化组织中针对特定需求的调整,与 HP 相比产生了额外的协同作用。这进一步增加了时间相邻肌肉协同作用的重叠,以提供足够的运动控制鲁棒性,以完成更苛刻的运动任务,同时应对行走过程中与病理相关的运动缺陷。
更新日期:2021-01-27
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