Abstract

Sulfonamide moiety is the backbone of various antimicrobial, anticancer, antiglaucoma, anticonvulsant, uricosuric agents, and numerous other drugs. The age-old demand of sulfonamides as powerful antimicrobial agents is still in vogue and will never lose its favor for having the facilities of cheap availability, low toxicity, and excellent activity against bacterial infections. Besides their medicinal values, the sulfonamide functional group has tremendous synthetic applications. Reflecting on their diverse roles, many powerful methodologies have been developed for the synthesis of sulfonamide. This present literary survey particularly spotlights the synthesis of sulfonamide under green conditions. A critical view on the mechanistic aspects of selected examples gives extra dimension to this review.

抽象的

磺酰胺部分是各种抗微生物剂，抗癌剂，抗青光眼，抗惊厥药，尿酸排泄药和许多其他药物的骨干。磺酰胺类作为强大的抗菌剂的古老需求一直在流行，并且永远不会因其具有廉价可获得性，低毒性和出色的抗细菌感染活性的设施而受到青睐。磺酰胺官能团除具有药用价值外，还具有巨大的合成应用价值。考虑到它们的不同作用，已经开发了许多强大的合成磺酰胺的方法。本次文学调查特别着重于在绿色条件下合成磺酰胺。对选定示例的机械方面的批判性观点为此次审查提供了更多的内容。