Abstract

Herein we report the multicomponent synthesis of the bis(indolyl)methane derivatives in a ball mill. The reaction was carried out under solvent-free conditions using only the Lewis acid-surfactant-SiO₂ composite nanocatalyst (LASSC) prepared in situ. The unsymmetrical bis(indolyl) methane derivatives containing nitro or fluorine substitution with a yield of 72%–92% were obtained in a short reaction time. Within we verified that under the action of the combined catalyst of AlCl₃·6H₂O + SDS + SiO₂, the method of preparing unsymmetrical bis(indolyl)methane by mechanical grinding without solvent has obvious advantages. Finally, we inspected that the catalysis system can be used eight times without a significant decrease in activity.

抽象的

在本文中，我们报道了在球磨机中双（吲哚基）甲烷衍生物的多组分合成。该反应在无溶剂条件下仅使用原位制备的路易斯酸表面活性剂-SiO ₂复合纳米催化剂（LASSC）进行。在较短的反应时间内即可获得具有硝基或氟取代基的不对称双（吲哚基）甲烷衍生物，产率为72％–92％。我们证实了在AlCl ₃ ·6H ₂ O + SDS + SiO ₂复合催化剂的作用下，无溶剂机械研磨制备不对称双（吲哚基）甲烷的方法具有明显的优势。最后，我们检查了该催化体系可以使用八次而活性没有明显降低。