当前位置: X-MOL 学术Synth. Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Solvent-free multi-component synthesis of unsymmetrical bis(indolyl)alkanes with Lewis acid-surfactant-SiO2 as nanocatalyst
Synthetic Communications ( IF 1.8 ) Pub Date : 2021-01-27 , DOI: 10.1080/00397911.2021.1874016
Zhiqiang Wu 1, 2 , Gang Wang 2 , Zhenliang Li 1 , Enke Feng 1 , Yanping Liang 2 , Haijuan Zhan 2 , Wanyi Liu 2
Affiliation  

Abstract

Herein we report the multicomponent synthesis of the bis(indolyl)methane derivatives in a ball mill. The reaction was carried out under solvent-free conditions using only the Lewis acid-surfactant-SiO2 composite nanocatalyst (LASSC) prepared in situ. The unsymmetrical bis(indolyl) methane derivatives containing nitro or fluorine substitution with a yield of 72%–92% were obtained in a short reaction time. Within we verified that under the action of the combined catalyst of AlCl3·6H2O + SDS + SiO2, the method of preparing unsymmetrical bis(indolyl)methane by mechanical grinding without solvent has obvious advantages. Finally, we inspected that the catalysis system can be used eight times without a significant decrease in activity.



中文翻译:

路易斯酸表面活性剂-SiO2为纳米催化剂的无溶剂双组分不对称双(吲哚基)烷烃的合成

抽象的

在本文中,我们报道了在球磨机中双(吲哚基)甲烷衍生物的多组分合成。该反应在无溶剂条件下仅使用原位制备的路易斯酸表面活性剂-SiO 2复合纳米催化剂(LASSC)进行。在较短的反应时间内即可获得具有硝基或氟取代基的不对称双(吲哚基)甲烷衍生物,产率为72%–92%。我们证实了在AlCl 3 ·6H 2 O + SDS + SiO 2复合催化剂的作用下,无溶剂机械研磨制备不对称双(吲哚基)甲烷的方法具有明显的优势。最后,我们检查了该催化体系可以使用八次而活性没有明显降低。

更新日期:2021-03-10
down
wechat
bug