Abstract

Mechanically enhanced poloxamer (F127)-based injectable hydrogels in the presence of hyaluronic acid (HA) and three types of cyclodextrin (CD) molecules were prepared. With the addition of HA to the F127 system, higher strain values to break down the interactions between the micelles were obtained. The formulations exhibit more frequency-dependent behavior than F127–HA gels with the inclusion of CD molecules. All the F127–HA–CD formulations containing α-, β- and γ-CD were found in the injectable range and the viscosity values increased considerably when mucin was added to the triple component formulations that prove the mucoadhesive properties of the gels.

摘要

在透明质酸 (HA) 和三种类型的环糊精 (CD) 分子存在下，制备了基于机械增强型泊洛沙姆 (F127) 的可注射水凝胶。在 F127 系统中添加 HA 后，获得了更高的应变值来破坏胶束之间的相互作用。与包含 CD 分子的 F127-HA 凝胶相比，该配方表现出更多的频率依赖性行为。所有含有α -、β - 和γ -CD的 F127–HA–CD 制剂都发现在可注射范围内，当将粘蛋白添加到证明凝胶的粘膜粘附特性​​的三组分制剂中时，粘度值显着增加。