Abstract

Although amorphous calcium phosphate has been a mature research object in the medicine field, its application in drug carriers remains restricted due to its easy agglomeration and poor dispersion stability. Accordingly, the ACP was modified with hyaluronic acid (HA) and hexametaphosphate ((NaPO₃)₆), the amorphous structure can be kept for more than 3 months based on HA stabilizers, the dispersion can be maintained for about one month owing to the (NaPO₃)₆. In vitro, the Cur-HA-ACP-(NaPO₃)₆ nanoparticles showed high drug loading, good pH response performance and favorable antitumor ability. Overall, Cur loaded HA-ACP nanoparticles exhibited a great potential for anticancer chemotherapeutics.

摘要

虽然无定形磷酸钙在医药领域已成为成熟的研究对象，但由于其易团聚、分散稳定性差等问题，其在药物载体中的应用仍受到限制。因此，用透明质酸（HA）和六偏磷酸盐（（NaPO ₃）₆）对ACP进行了改性，在HA稳定剂的基础上，无定形结构可以保持3个月以上，分散体可以保持1个月左右。 (NaPO ₃ ) ₆．在体外，Cur-HA-ACP-(NaPO ₃ ) ₆纳米粒表现出高载药量、良好的pH响应性能和良好的抗肿瘤能力。总体而言，载有 Cur 的 HA-ACP 纳米颗粒在抗癌化疗方面表现出巨大的潜力。