Tight junction proteins in the small intestine and prefrontal cortex of female rats exposed to stress of chronic isolation starting early in life,Neurogastroenterology & Motility

当前位置： X-MOL 学术 › Neurogastroenterol. Motil. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tight junction proteins in the small intestine and prefrontal cortex of female rats exposed to stress of chronic isolation starting early in life
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-01-26 , DOI: 10.1111/nmo.14084
Peter Karailiev ₁ , Natasa Hlavacova ₁ , Magdalena Chmelova ₁ , Natalie Z M Homer ₂ , Daniela Jezova ₁

Affiliation

Simultaneous evaluation of barrier protein expression in the gut and the brain and their modulation under stress conditions have not been studied before now. As the permeability and function of the gut and blood-brain barrier are different and both express the MRs, we hypothesized that stress of post-weaning social isolation induces changes in tight junction protein expression in the gut which are (1) independent of changes in the brain and (2) are mediated via the mineralocorticoid receptor (MR).

中文翻译：

雌性大鼠小肠和前额叶皮层的紧密连接蛋白暴露于生命早期开始的慢性隔离压力

目前尚未研究过同时评估肠道和大脑中的屏障蛋白表达及其在压力条件下的调节。由于肠道和血脑屏障的通透性和功能不同并且都表达 MR，我们假设断奶后社会隔离的压力会诱导肠道中紧密连接蛋白表达的变化，这些变化是（1）独立于大脑和 (2) 通过盐皮质激素受体 (MR) 介导。

更新日期：2021-01-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文