Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui,Journal of Natural Products

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Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-01-26 , DOI: 10.1021/acs.jnatprod.0c01248
Joe Bracegirdle ₁ , Luke J Stevenson ₁ , Abigail V Sharrock ₁ , Michael J Page ₂ , Jan A Vorster , Jeremy G Owen ₁ , David F Ackerley ₁ , Robert A Keyzers ₁

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LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.

中文翻译：

来自新西兰被囊动物 Synoicum kuranui 的水合红豆内酯

对新西兰被囊类动物Synoicum kuranui提取物的 LCMS 分析显示了大量新红豆内酯的证据。在质谱引导的分离程序之后，新的水合 rubrolide V 和 W（5和6）以及先前报道的 rubrolide G（3）被分离出来，并使用 MS 和 NMR 表征。将这些化合物的抗菌和细胞细胞毒活性与强效抗 MRSA 化合物 rubrolide A 进行了比较；跨 C-5/C-6 键的水合作用被证明可以消除抗菌活性。

更新日期：2021-02-26

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