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The relationship between positivity for COVID-19 RT-PCR and symptoms, clinical findings, and mortality in Turkey
Expert Review of Molecular Diagnostics ( IF 3.9 ) Pub Date : 2021-02-08 , DOI: 10.1080/14737159.2021.1882305
Erkan Ozcan 1 , Serap Yavuzer 2 , Betul Borku Uysal 2 , Mehmet Sami Islamoglu 2 , Hande Ikitimur 2 , Omer Faruk Unal 2 , Yunus Emre Akpinar 2 , Serhat Seyhan 2 , Suna Koc 2 , Hakan Yavuzer 3 , Mahir Cengiz 2
Affiliation  

ABSTRACT

Introduction: This study aimed to assess the correlation between nucleic acid amplification test (real-time reverse transcription-polymerase chain reaction, RT-PCR) positivity of patients presenting with suspected COVID-19 and pneumonic infiltration consistent with COVID-19-specific pneumonia diagnosis on thoracic computed tomography (CT), with symptoms, laboratory findings, and clinical progression.

Methods: The study included 286 patients (female:male 131:155; mean age, 53.3 ± 17.9 years) who were divided into two groups according to their RT-PCR test results. The symptoms, laboratory examinations, clinical findings, and thoracic CT imaging of the patients were evaluated.

Results: While the physical examination, comorbidities, and total CT scores were similar between the groups, taste/smell abnormalities were observed more frequently in the PCR-positive group. The use of moxifloxacin, lopinavir/ritonavir, and tocilizumab was higher in the PCR-positive group (p = 0.016, p < 0.001, and p = 0.002, respectively). The duration of hospitalization, intensive care requirement, and mortality rate of the studied groups did not differ between the groups.

Conclusions: Among patients presenting with suspected COVID-19 and pneumonic infiltration consistent with COVID-19 on thoracic CT, the symptoms, physical examination, total CT scores, duration of hospitalization, intensive care requirement, and mortality rate were similar between RT-PCR-positive and RT-PCR-negative patients. However, PCR-positive patients appeared to require more specific treatments.



中文翻译:

COVID-19 RT-PCR阳性与土耳其的症状,临床发现和死亡率之间的关系

摘要

简介:这项研究旨在评估疑似COVID-19的患者的核酸扩增试验(实时逆转录-聚合酶链反应,RT-PCR)阳性与肺炎浸润(与COVID-19特异性肺炎诊断一致)之间的相关性在胸部计算机断层扫描(CT)上进行,包括症状,实验室检查结果和临床进展。

方法:该研究纳入了286例患者(女:男131:155;平均年龄:53.3±17.9岁),根据其RT-PCR测试结果分为两组。对患者的症状,实验室检查,临床发现和胸部CT成像进行了评估。

结果:尽管两组之间的体格检查,合并症和总CT评分相似,但PCR阳性组中的味觉/气味异常更为常见。在PCR阳性组中莫西沙星,洛匹那韦/利托那韦和托珠单抗的使用率更高(分别为p = 0.016,p <0.001和p = 0.002)。研究组的住院时间,重症监护需要和死亡率没有差异。

结论:在胸部CT表现为疑似COVID-19和肺炎浸润与COVID-19一致的患者中,症状,体格检查,CT总评分,住院时间,重症监护要求和死亡率相似。阳性和RT-PCR阴性的患者。但是,PCR阳性的患者似乎需要更具体的治疗。

更新日期:2021-03-27
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