Ruthenium(II)‐Catalyzed C?H/N?H Carbonylative Cyclization of 2‐Aryl Quinazolinones with Isocyanates as CO Surrogates,Bulletin of the Korean Chemical Society

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Ruthenium(II)‐Catalyzed C?H/N?H Carbonylative Cyclization of 2‐Aryl Quinazolinones with Isocyanates as CO Surrogates
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2021-01-25 , DOI: 10.1002/bkcs.12228
Jin Ho Choi ₁ , Hak Do Kim ₁ , Ju Young Kang ₁ , Taejoo Jeong ₁ , Prithwish Ghosh ₁ , In Su Kim ₁

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The ruthenium(II)‐catalyzed CH carbonylation of 2‐aryl quinazolinones with isocyanates as carbonyl sources is described. The developed method provides direct access to biologically relevant isoindoloquinazolinone core through CH aminocarbonylation followed by intramolecular annulation. A broad range of substrate scope and functional group tolerance were observed. Gram‐scale reactions and synthetic transformations demonstrate the synthetic potential of this protocol.

中文翻译：

钌（II）催化的C ？H / N ？以异氰酸酯作为CO替代物的2芳基喹唑啉酮的H羰基化环化反应

描述了钌（II）催化的2-芳基喹唑啉酮的CH羰基化，其中异氰酸酯为羰基来源。所开发的方法可通过CH氨基羰基化，然后进行分子内环化，直接获得生物学上相关的异吲哚并喹唑啉酮核心。观察到广泛的底物范围和官能团耐受性。革兰氏反应和合成转化证明了该方案的合成潜力。

更新日期：2021-03-18

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