Benzothiazole‐Phenothiazine Conjugate Based Molecular Probe for the Differential Detection of Glycated Albumin,Israel Journal of Chemistry

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Benzothiazole‐Phenothiazine Conjugate Based Molecular Probe for the Differential Detection of Glycated Albumin
Israel Journal of Chemistry ( IF 2.3 ) Pub Date : 2021-01-26 , DOI: 10.1002/ijch.202000098
Ashish Kumar ₁ , Lakshmi Priya Datta ₁ , Sourav Samanta ₁ , Harshit Arora ₁ , Thimmaiah Govindaraju ₁

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Glycation of albumin proteins is considered the pathophysiological hallmark of several chronic fatal disorders, including diabetes mellitus (DM) and Alzheimer's disease (AD). The optical detection of glycated albumin is a simple and cost‐effective tool with diagnostic implications for DM and AD. Herein, we developed a cyano derivative of the benzothiazole‐phenothiazine conjugate (T_CNP) ‐based far‐red fluorescence probe for the differential detection of glycated bovine serum albumin (BSA_G) over native BSA and oxidized BSA (BSA_O). The selective fluorescence enhancement of T_CNP in the presence of native BSA and BSA_O and significant quenching in the presence of BSA_G account for the distinct interaction between the probe and different structural variants of BSA. The high photostability and differential response towards native BSA and BSA_G infer that T_CNP is a potential molecular tool to assess the glycation induced structural changes of albumins.

中文翻译：

苯并噻唑-吩噻嗪共轭分子探针用于糖化白蛋白的差异检测

白蛋白的糖基化被认为是几种慢性致命疾病的病理生理学标志，包括糖尿病（DM）和阿尔茨海默氏病（AD）。糖化白蛋白的光学检测是一种简单且具有成本效益的工具，对DM和AD具有诊断意义。本文中，我们开发了基于苯并噻唑-吩噻嗪共轭物（T _CN P）的氰基衍生物的远红外荧光探针，用于相对于天然BSA和氧化BSA（BSA _O）进行糖化牛血清白蛋白（BSA _G）的差异检测。在天然BSA和BSA _O存在下T _CN P的选择性荧光增强，在BSA _G存在下显着淬灭解释了探针与BSA的不同结构变体之间的独特相互作用。高光稳定性和对天然BSA和BSA _G的差异反应表明，_TCNP是评估糖基化诱导的白蛋白结构变化的潜在分子工具。

更新日期：2021-01-26

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