Synthesis of [4 S ‐ 2 H]NADH, [4 R ‐ 2 H]NADH, [4‐ 2 H 2 ]NADH and [4‐ 2 H]NAD + cofactors through heterogeneous biocatalysis in heavy water,Journal of Labelled Compounds and Radiopharmaceuticals

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Synthesis of [4 S ‐ 2 H]NADH, [4 R ‐ 2 H]NADH, [4‐ 2 H 2 ]NADH and [4‐ 2 H]NAD + cofactors through heterogeneous biocatalysis in heavy water
Journal of Labelled Compounds and Radiopharmaceuticals ( IF 0.9 ) Pub Date : 2021-01-26 , DOI: 10.1002/jlcr.3899
Jack S Rowbotham ₁ , Adam P Hardy ₁ , Holly A Reeve ₁ , Kylie A Vincent ₁

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This practitioner protocol describes the synthesis of a family of deuterated nicotinamide cofactors: [4S-2 H]NADH, [4R-2 H]NADH, [4-2 H2 ]NADH and [4-2 H]NAD+ . The application of a recently developed H2 -driven heterogeneous biocatalyst enables the cofactors to be prepared with high (>90%) 2 H-incorporation with 2 H2 O as the only isotope source.

中文翻译：

重水中多相生物催化合成[4 S - 2 H]NADH、[4 R - 2 H]NADH、[4- 2 H 2 ]NADH和[4- 2 H]NAD + 辅因子

该从业者方案描述了一系列氘代烟酰胺辅因子的合成：[4S-2 H]NADH、[4R-2 H]NADH、[4-2 H2]NADH 和 [4-2 H]NAD+。最近开发的 H2 驱动的非均相生物催化剂的应用使辅因子能够以高（>90%）的 2 H 结合率制备，其中 2 H2 O 作为唯一的同位素来源。

更新日期：2021-01-26

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